
Most people who know about GABA think of it as the “chill pill."
Why?
Because gamma-aminobutyric acid (GABA) is a neurotransmitter responsible for regulating the nervous system, and works by calming the brain to slow down nerve signals in the central nervous system, reducing feelings of anxiety.
But GABA also plays a role in the healthy functioning of the body’s immune and endocrine systems, as well as in the regulation of appetite and metabolism. There’s also emerging research about GABA’s role in gut health and gastrointestinal function, where it may work to support motility, control inflammation and support immune system function, and help regulate hormone activity.
Low GABA activity in the body is associated with:
- Anxiety
- Chronic stress
- Depression
- Difficulty concentrating and memory problems
- Muscle pain and headaches
- Insomnia and other sleep problems
GABA for Weight Management
Teri Cochrane, an integrative practitioner who is also one of our guest bloggers, uses Chewable Gaba 200 Mg in her practice as an aid for weight management. For the gamma-aminobutyric acid weight loss question, glucose metabolism is where it starts, and GABA is critically important there. By managing our blood sugar, we can promote the healthy performance of insulin, the fat-storage hormone. Because of its support of glucose metabolism, GABA is actually considered to have anti-obesity effects rather than cause weight gain, making it a useful tool in your fat-loss arsenal.
GABA also helps with the production of human growth hormone, linked to an increase in lean muscle mass. One study found that “taking a GABA supplement led to a 400% increase in HGH [human growth hormone] at rest and a 200% increase following exercise, and that GABA may also increase HGH levels by improving your sleep, since your nighttime growth hormone release is linked to sleep quality and depth."
Other Benefits of GABA
Sleep
GABA enables the body and mind to relax and fall asleep, and to sleep soundly throughout the night. Low GABA activity is linked to insomnia and disrupted sleep. In one study, GABA levels in people with insomnia were almost 30% lower than in people without insomnia.
Stress and anxiety
As a natural chemical the body produces, GABA’s primary role is to diminish the activity of neurons in the brain and central nervous system, which puts the body in a greater state of relaxation and alleviates stress and anxiety. Supplemental GABA may benefit sleep by aiding relaxation and providing relief from anxiety and stress.
Blood pressure
GABA supplements are sometimes used by people as a natural way to lower blood pressure. GABA may help support healthy blood pressure.
Frequently Asked Questions
How much GABA to take for weight loss?
The honest truth is that there’s no weight loss dose of GABA. Human studies looking at it for that are pretty limited. Instead, people typically take GABA at night for sleep and relaxation. At Village Green Apothecary, we can help you find a dose and form tailored to your needs, with your practitioner's input.
Does GABA cause weight gain?
GABA does not appear to cause weight gain, though its relationship to blood sugar and insulin levels may explain why some healthcare practitioners include it in a weight loss plan. If anything, the evidence points toward GABA being helpful for maintaining healthy blood sugar levels. If you take a new supplement and have unexpected side effects, talk to your healthcare provider.
GABA does not appear to make you gain weight. Because of its support of glucose metabolism and healthy blood sugar levels, GABA is actually considered to have anti-obesity effects rather than cause weight gain, which is why some practitioners include it in a weight loss plan. If you have unexpected side effects, talk to your healthcare provider.
Does GABA suppress appetite?
GABA has also been linked with appetite and metabolism, which is why appetite is a recurring topic in these discussions. There is currently little direct evidence from humans that taking a GABA supplement can suppress appetite. However, GABA has been shown to reduce stress-related brain signals, and both stress and sleep can affect appetite. So rather than considering it a magic bullet for weight loss, think of it as one part of a larger puzzle.
How GABA Influences Blood Sugar and Fat?
Now, here is where the gamma-aminobutyric acid weight loss story starts getting really interesting. GABA helps with glucose metabolism. This means that your blood sugar levels become more stable, allowing the fat storing hormone, insulin, to function better. The relationship between glucose and GABA is what ties together most of the claims about GABA causing fat loss.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
References
- PubMed
- PubMed
- PubMed
- Effects of Oral Gamma-Aminobutyric Acid (GABA) Administration on Stress and Sleep in Humans: A Systematic Review (2020)
- Neurosteroids and GABA-A Receptor Function (2011)
- Therapeutic Anti-Depressant Potential of Microbial GABA Produced by Lactobacillus rhamnosus Strains for GABAergic Signaling Restoration and Inhibition of Addiction-Induced HPA Axis Hyperactivity (2022)
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